In December 2007, the Adjei-Bekoe committee submitted a report to Government of Ghana for a Presidential committee to be set up to prepare a draft nuclear power policy and terms of reference for the additional work needed for a technical and financial feasibility study of introducing nuclear energy into Ghana’s energy mix with a programme and time frame for action. The Presidential Committee came to be known as Ghana Nuclear Power Programme Organization (GNPPO). In January 2008, cabinet decided to include nuclear into Ghana’s energy mix based on the Adjei-Bekoe committee report. As a result, various national technical groups were established to be in charge of specific nuclear infrastructural development issues. However, failure on the part of these technical groups brought the nuclear power programme to a standstill.

In February 2014, Prof. B.J.B Nyarko, the substantive Director-General of GAEC saw the need to establish Nuclear Power Centre (NPC) under the National Nuclear Research Institute (NNRI) to provide technical support to GNPPO. This move by the director-General birthed NPC.

However, in January 2015, IAEA reviewed Ghana’s nuclear power program and noted that NPC’s establishment under a research institute stifled its core function as a development activity. As a result, it was recommended that NPC be upgraded to an institute’s level so as to be an independent body and thus perform its core mandate.

In September 2015, a memo was submitted to the board and approval was given for the establishment of Nuclear Power Institute (NPI). Although technically NPI came to existence when the approval was given in September 2015, it was officially outdoored as an institute under GAEC in January 2016.